Pharmacokinetics and depressor effect of delapril in patients with essential hypertension
In: Clinical Pharmacology and Therapeutics, Jg. 41 (1987), S. 74-79
Online
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Zugriff:
The pharmacokinetics and depressor effect of a nonsulfhydryl angiotensin-converting enzyme inhibitor, delapril, was assessed by administering a single dose of 30 mg to nine patients with mild to moderate essential hypertension. Orally administered delapril is a prodrug and must be deesterified to its active metabolites, delapril diacid and 5-hydroxy delapril diacid. The pharmacokinetic parameters for delapril, delapril diacid, and 5-hydroxy delapril diacid were, respectively: t½ 0.30, 1.21, and 1.40 hours; Cmax 489, 635, and 229 ng/ml; AUC 572, 1859, and 948 ng · hr/ml. Delapril produced significant decreases in systolic blood pressure and angiotensin-converting enzyme activity 24 hours after dosing. There were no significant changes in the endogeneous creatinine clearance after the drug. Thus delapril may represent a useful antihypertensive agent for control of blood pressure in patients with essential hypertension. Clinical Pharmacology and Therapeutics (1987) 41, 74–79; doi:10.1038/clpt.1987.12
Titel: |
Pharmacokinetics and depressor effect of delapril in patients with essential hypertension
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Autor/in / Beteiligte Person: | Miyajima, Eiji ; Ohta, Takashi ; Ikeda, Akihiko ; Kaneko, Yoshihiro ; Yasuda, Gen ; Shionoiri, Hiroshi |
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Zeitschrift: | Clinical Pharmacology and Therapeutics, Jg. 41 (1987), S. 74-79 |
Veröffentlichung: | Springer Science and Business Media LLC, 1987 |
Medientyp: | unknown |
ISSN: | 1532-6535 (print) ; 0009-9236 (print) |
DOI: | 10.1038/clpt.1987.12 |
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