Foxp1 is an essential transcriptional regulator of B cell development
In: Nature Immunology, Jg. 7 (2006-07-02), S. 819-826
Online
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Zugriff:
Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220+ fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.
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Foxp1 is an essential transcriptional regulator of B cell development
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Autor/in / Beteiligte Person: | Rao, Anjana ; Borde, Madhuri ; Maika, Shan ; Nardone, Julie ; Hu, Hui ; Tucker, Philip W. ; Allred, Laura ; Wang, Bin |
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Zeitschrift: | Nature Immunology, Jg. 7 (2006-07-02), S. 819-826 |
Veröffentlichung: | Springer Science and Business Media LLC, 2006 |
Medientyp: | unknown |
ISSN: | 1529-2916 (print) ; 1529-2908 (print) |
DOI: | 10.1038/ni1358 |
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