Results of the PERSIST-1 phase III study of pacritinib (PAC) versus best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF)
In: Journal of Clinical Oncology, Jg. 33 (2015-06-20), S. LBA7006
Online
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Zugriff:
LBA7006 Background: PAC is a potent JAK2 inhibitor without significant JAK1 inhibition with minimal myelosuppression in early-phase studies in MF. Methods: The efficacy and safety of daily oral PAC was compared to BAT (2:1 randomization stratified for risk and platelet count). The 10 endpoint was the proportion of ITT patients (pts) achieving ≥ 35% spleen volume reduction (SVR) at week (wk) 24 by centrally reviewed MRI or CT. Secondary endpoints included the proportion achieving ≥ 50% reduction in total symptom score (TSS) at wk 24 using the MPN Symptom Assessment Form. Results: Patients:327 were enrolled (PAC:220, BAT:107), 62% with 10 MF. Median time from diagnosis was 1.12 years (PAC 0.99, BAT 1.60): 32% and 15% had a platelet counts < 100,000/µL or 35% reduction in spleen volume at data cutoff. TSS composite V1 + V2 response rates were 24.5%for PAC vs. 6.5% for BAT (p
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Results of the PERSIST-1 phase III study of pacritinib (PAC) versus best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF)
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Autor/in / Beteiligte Person: | Cernohous, Paul ; Egyed, Miklos ; Mead, Adam J. ; Tosi, Patrizia ; Suvorov, Aleksandr ; Vannucchi, Alessandro M. ; Zachee, Pierre ; Perkins, Andrew C. ; Farber, Charles M. ; Ganly, Peter ; Nangalia, Jyoti ; Dean, James P. ; Schouten, Harry C. ; Mayer, Jiri ; Szoke, Anita ; Jourdan, Eric ; Mesa, Ruben A. ; Kiladjian, Jean-Jacques ; Scheid, Christof ; Harrison, Claire N. |
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Zeitschrift: | Journal of Clinical Oncology, Jg. 33 (2015-06-20), S. LBA7006 |
Veröffentlichung: | American Society of Clinical Oncology (ASCO), 2015 |
Medientyp: | unknown |
ISSN: | 1527-7755 (print) ; 0732-183X (print) |
DOI: | 10.1200/jco.2015.33.18_suppl.lba7006 |
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