Effects of Angiotensin-(1-7) on Forearm Circulation in Normotensive Subjects and Patients With Essential Hypertension
In: Hypertension, Jg. 38 (2001-07-01), S. 90-94
Online
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Zugriff:
Previous animal studies have shown that angiotensin (Ang)-(1-7) is a biologically active component of the renin-angiotensin system, acting as a vasoactive agent, and may play a role in the blood pressure regulation. There is little information, however, on the effect of Ang-(1-7) on human circulation or the mechanism of its action. To investigate the effect of Ang-(1-7) on forearm circulation and to determine whether this effect is altered in patients with essential hypertension, we measured change in forearm blood flow using venous occlusion plethysmography in response to intra-arterial infusion of Ang-(1-7) (10 −10 , 10 −9 , and 10 −8 mol/min; for 5 minutes) in normotensive control subjects (n=8) and patients with essential hypertension (n=8). Infusion of Ang-(1-7) significantly increased the forearm blood flow response in a dose-dependent manner in both normotensive control subjects (28.7±9.7%, at 10 −8 mol/min; P −8 mol/min; P N G -monomethyl- l -arginine, a nitric oxide synthesis inhibitor, did not alter the forearm blood flow response to Ang-(1-7) in either group. These findings suggest that Ang-(1-7) causes vasodilation in forearm circulation of normotensive subjects and patients with essential hypertension through a pathway that is independent of nitric oxide synthesis.
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Effects of Angiotensin-(1-7) on Forearm Circulation in Normotensive Subjects and Patients With Essential Hypertension
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Autor/in / Beteiligte Person: | Kajiyama, Goro ; Matsuura, Hideo ; Higashi, Yukihito ; Sasaki, Shota ; Oshima, Tetsuya ; Nakagawa, Keigo |
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Zeitschrift: | Hypertension, Jg. 38 (2001-07-01), S. 90-94 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 2001 |
Medientyp: | unknown |
ISSN: | 1524-4563 (print) ; 0194-911X (print) |
DOI: | 10.1161/01.hyp.38.1.90 |
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