Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil
In: Natural product research, Jg. 29 (2015-02-25), Heft 20
Online
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Zugriff:
Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC–MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil.
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Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil
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Autor/in / Beteiligte Person: | Marcos José Salvador ; Alessandra Freitas Serain ; Carvalho, João ; Siqueira, Carlos ; Nathalia Luiza Andreazza ; Ana Cláudia Oliveira de Souza ; Caroline C. de Lourenço ; Mesquita, Juliana T. ; Aislan C R F Pascoal ; Tempone, Andre G. ; Ana Lúcia Tasca Gois Ruiz |
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Zeitschrift: | Natural product research, Jg. 29 (2015-02-25), Heft 20 |
Veröffentlichung: | 2015 |
Medientyp: | unknown |
ISSN: | 1478-6427 (print) |
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