Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
In: Cell, Jg. 89 (1997-04-01), Heft 1, S. 115-126
Online
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Zugriff:
The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB-mediated transcription and new protein synthesis. We isolated several downstream genes, one of which encodes a neuron-specific ubiquitin C-terminal hydrolase. This rapidly induced gene encodes an enzyme that associates with the proteasome and increases its proteolytic activity. This regulated proteolysis is essential for long-term facilitation. Inhibiting the expression or function of the hydrolase blocks induction of long-term but not short-term facilitation. We suggest that the enhanced proteasome activity increases degradation of substrates that normally inhibit long-term facilitation. Thus, through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage.
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Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
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Autor/in / Beteiligte Person: | Chain, Daniel G. ; Pei, Wanzheng ; Martin, Kelsey C. ; Kandel, Eric R. ; Schwartz, James H. ; Inokuchi, Kaoru ; Ghirardi, Mirella ; Hegde, Ashok N. ; Casadio, Andrea |
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Zeitschrift: | Cell, Jg. 89 (1997-04-01), Heft 1, S. 115-126 |
Veröffentlichung: | Elsevier BV, 1997 |
Medientyp: | unknown |
ISSN: | 0092-8674 (print) |
DOI: | 10.1016/s0092-8674(00)80188-9 |
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