Gamma Interferon Is Essential for Clearing Mycobacterium genavense Infection
In: Infection and Immunity, Jg. 68 (2000-06-01), S. 3720-3723
Online
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Zugriff:
Factors determining the in vivo replication of the opportunistic pathogen Mycobacterium genavense are largely unknown. Following intravenous injection of a patient isolate, M. genavense could not be recovered by culture or detected by PCR in the livers or spleens of infected BALB/c mice. In contrast, M. genavense was found to chronically persist and multiply in the livers and spleens of intravenously infected syngeneic gamma-interferon-gene-deficient (GKO) mice as evidenced by acid-fast stains of infected tissues and recovery by both PCR and liquid culture following organ homogenization. In GKO mice, M. genavense elicited a chronic inflammatory response, resulting in marked splenomegaly and extensive lymphadenopathy. Granulomatous lesions in the livers of GKO mice were diffuse, were composed of monocytes, neutrophils, and CD3 + cells, and were histochemically negative for inducible nitric oxide synthase.
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Gamma Interferon Is Essential for Clearing Mycobacterium genavense Infection
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Autor/in / Beteiligte Person: | Ehlers, Stefan ; Richter, Elvira |
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Zeitschrift: | Infection and Immunity, Jg. 68 (2000-06-01), S. 3720-3723 |
Veröffentlichung: | American Society for Microbiology, 2000 |
Medientyp: | unknown |
ISSN: | 1098-5522 (print) ; 0019-9567 (print) |
DOI: | 10.1128/iai.68.6.3720-3723.2000 |
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