IL-1α Is Essential for Oviduct Pathology during Genital Chlamydial Infection in Mice
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 205 (2020-05-26), Heft 11
Online
unknown
Zugriff:
Chlamydia trachomatis infection of the female genital tract can lead to irreversible fallopian tube scarring. In the mouse model of genital infection using Chlamydia muridarum, IL-1R signaling plays a critical role in oviduct tissue damage. In this study, we investigated the pathologic role of IL-1α, one of the two proinflammatory cytokines that bind to IL-1R. Il1a−/− mice infected with C. muridarum cleared infection at their cervix at the same rate as wild-type (WT) mice, but were significantly protected from end point oviduct damage and fibrosis. The contribution of IL-1α to oviduct pathology was more dramatic than observed in mice deficient for IL-1β. Although chlamydial burden was similar in WT and Il1a−/− oviduct during peak days of infection, levels of IL-1β, IL-6, CSF3, and CXCL2 were reduced in Il1a−/− oviduct lysates. During infection, Il1a−/− oviducts and uterine horns exhibited reduced neutrophil infiltration, and this reduction persisted after the infection resolved. The absence of IL-1α did not compromise CD4 T cell recruitment or function during primary or secondary chlamydial infection. IL-1α is expressed predominantly by luminal cells of the genital tract in response to infection, and low levels of expression persisted after the infection cleared. Ab-mediated depletion of IL-1α in WT mice prevented infection-induced oviduct damage, further supporting a key role for IL-1α in oviduct pathology.
Titel: |
IL-1α Is Essential for Oviduct Pathology during Genital Chlamydial Infection in Mice
|
---|---|
Autor/in / Beteiligte Person: | Nagarajan, Uma M. ; Gyorke, Clare E. ; Zhang, Yugen ; Kollipara, Avinash ; Allen, John A. ; J. Ashley Ezzell ; Darville, Toni ; Montgomery, Stephanie A. |
Link: | |
Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 205 (2020-05-26), Heft 11 |
Veröffentlichung: | 2020 |
Medientyp: | unknown |
ISSN: | 1550-6606 (print) |
Schlagwort: |
|
Sonstiges: |
|