Doxazosin in the treatment of essential hypertension in general medical practice in Latin America
In: American Heart Journal, Jg. 121 (1991), S. 329-335
Online
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Zugriff:
This Latin American study assessed in the general practice setting the efficacy and tolerance of once-daily doxazosin in the treatment of mild or moderate essential hypertension (sitting diastolic blood pressure, 95 to 115 mm Hg). Patients (n = 220) were treated with doxazosin for 12 weeks as monotherapy or in combination with other antihypertensive agents. At the final visit, doxazosin produced a mean change in sitting systolic/diastolic blood pressure of -18.4/-14.4 mm Hg, at a mean daily dose of 4.3 mg. One hundred sixty-three (77.6%) of the 210 evaluable patients were considered a therapeutic success. Lipid analyses identified a statistically significant (p = 0.02) reduction in total serum cholesterol (4.85%) and an overall decrease in triglyceride levels (5.12%). According to the Framingham Heart Study equation, doxazosin produced a highly significant (p less than 0.001) 20% reduction in the calculated probability of developing coronary heart disease in 10 years. Of the 220 patients evaluated, 54 (24.5%) reported side effects that were considered related to treatment. Ten (4.5%) patients reported side effects unrelated to treatment and 37 (16.8%) reported events of unknown relationship. Most side effects were mild or moderate and were tolerated or disappeared with continued treatment. Nine patients (4.1%) were discontinued from therapy and in 13 (5.9%) the dose was reduced. The most prevalent side effects were headache and dizziness. The investigator's overall assessment of antihypertensive efficacy was excellent or good for 176 patients (80.4%); tolerance was considered excellent or good in 193 patients (88.5%).(ABSTRACT TRUNCATED AT 250 WORDS)
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Doxazosin in the treatment of essential hypertension in general medical practice in Latin America
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Autor/in / Beteiligte Person: | Fonseca, Ricardo ; Marshall, Dennis ; Silva, Honorio |
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Zeitschrift: | American Heart Journal, Jg. 121 (1991), S. 329-335 |
Veröffentlichung: | Elsevier BV, 1991 |
Medientyp: | unknown |
ISSN: | 0002-8703 (print) |
DOI: | 10.1016/0002-8703(91)90867-h |
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