Effects of Satureja Khozestanica essential oil on hemoglobin A1C, serum urea and creatinine in alloxan-induced Type 1 diabetic adult rats

Introduction: The prevalence of diabetes in the world is rapidly rising. Hemoglobin A1C is the best marker for the control and management of diabetes. This study aimed to determine the protective effect of Satureja khozestanica essential oil (SKE) on hemoglobin A1C, urea and creatinine in diabetic rats. Materials and Methods: Thirty male rats were divided into three groups randomly group one as control, group two untreated diabetic, and group three treated with SKE by 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously (120 mg/kg). After 8 weeks, the levels of fasting blood glucose (FBG), hemoglobin A1C, urea and creatinine of all groups were analyzed. Also, free radical scavenging of SKE was determined. Results: The level of FBG, hemoglobin A1C, urea and creatinine decreased in the treated group significantly. Also, SKE and BHT as positive control showed remarkable scavenging activity on 2, 2-diphenyl-picrylhydrazyl (DPPH), respectively (IC50 5.30 ± 0.11 and 3.88 ± 0.12 ng/ml). Conclusion: This study showed that SKE exerts beneficial effects on the FBG, hemoglobin A1C, urea and creatinine level in Type 1 diabetic rats.