Oxidative stress protective effect of Dracocephalum multicaule essential oil against human cancer cell line
In: Natural Product Research, Jg. 28 (2014-01-31), S. 848-852
Online
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Zugriff:
In this study, we report the antioxidative and protective effect of essential oil of Dracocephalum multicaule on K562 cells. Our results demonstrated that monoterpenoids, including oxygenated and hydrocarbons, 71.5% and 28.3%, respectively, were the principal essential oils of D. multicaule. Perilla aldehyde (71.5%) and limonene (28.1%) were identified as the main components. Antioxidant studies based on the 2,2-diphenylpicrylhydrazyl assay indicated that the D. multicaule essential oil possesses a marked antioxidant and radical-scavenging activity with an IC50 value of 438.2 μg/mL. Pretreatment with essential oil and main constituents protected K562 cells 49.5% against H2O2-induced oxidative damage throughout increasing the activities of antioxidant enzymes and glutathione content in K562 cells. Collectively, D. multicaule essential oil and its main compounds especially in combinatory condition at a ratio of 7:3 with high antioxidant properties may be able to protect cells against oxidative stress induced by H2O2 through antioxidative mechanisms.
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Oxidative stress protective effect of Dracocephalum multicaule essential oil against human cancer cell line
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Autor/in / Beteiligte Person: | Sonboli, Ali ; Mohammad Ali Esmaeili ; Mohammad Hossein Mirjalili |
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Zeitschrift: | Natural Product Research, Jg. 28 (2014-01-31), S. 848-852 |
Veröffentlichung: | Informa UK Limited, 2014 |
Medientyp: | unknown |
ISSN: | 1478-6427 (print) ; 1478-6419 (print) |
DOI: | 10.1080/14786419.2014.881364 |
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