Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
In: Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Nature Communications Nature Communications, Jg. 12 (2021), Heft 1, S. 1-15
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Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhance phagocytosis by neutrophils. Apcs-/- mice are defective in vivo in terms of recruitment of neutrophils and phagocytosis in the lungs. Opsonic activity of SAP is dependent on the classical pathway of complement activation. In immunosuppressed mice, SAP administration protects hosts against A. fumigatus infection and death. In the context of a study of hematopoietic stem-cell transplantation, genetic variation in the human APCS gene is associated with susceptibility to invasive pulmonary aspergillosis. Thus, SAP is a fluid phase pattern recognition molecule essential for resistance against A. fumigatus.
The contribution of the European Commission (ERC project PHII-669415; FP7 project 281608 TIMER; ESA/ITN, H2020-MSCA-ITN-2015-676129), Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) (project FIRB RBAP11H2R9), Associazione Italiana Ricerca sul Cancro (AIRC IG-19014 and IG-21714, AIRC 5 × 1000 −9962 and −21147), the Italian Ministry of Health, the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) (NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023), the Fundação para a Ciência e Tecnologia (FCT) (UIDB/50026/2020, UIDP/50026/2020, PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017, CEECIND/04058/2018 and CEECIND/03628/2017), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 847507 and the “la Caixa” Foundation (ID 100010434) and FCT under the agreement LCF/PR/HR17/52190003 is gratefully acknowledged.
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Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
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Autor/in / Beteiligte Person: | Carvalho, Agostinho ; Maertens, Johan ; Botto, Marina ; Mercier, Toine ; Schorn, Tilo ; Lacerda, João F. ; Bottazzi, Barbara ; Lagrou, Katrien ; Laface, Ilaria ; Campos, António ; Mapelli, Sarah N. ; Petroni, Francesca ; Magrini, Elena ; Mantovani, Alberto ; Inforzato, Antonio ; Lambris, John D. ; Cunha, Cristina ; Parente, Raffaella ; Colombo, Federico ; Porte, Rémi ; Doni, Andrea ; Garlanda, Cecilia ; Repositório da Universidade de Lisboa |
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Zeitschrift: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Nature Communications Nature Communications, Jg. 12 (2021), Heft 1, S. 1-15 |
Veröffentlichung: | Springer Nature, 2021 |
Medientyp: | unknown |
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