Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

Faisal F Albaqami ; Abdel-Kader, Maged S. ; et al.

In: Molecules, Jg. 25 (2020-04-13), Heft 1786, p 1786, S. 1786-1786

Online unknown

Zugriff:

Cardiac hypertrophy is an independent risk factor of many cardiovascular diseases. Several cardiovascular protective properties of Cymbopogon proximus have been reported. However, no reports investigating the direct effect of C. proximus essential oil on the heart are available. The goal of this study was to explore the cardioprotective effect of C. proximus on cardiac hypertrophy and fibrosis. Male albino rats were administered C. proximus essential oil in the presence or absence of hypertrophic agonist isoproterenol. Cardiac hypertrophy and fibrosis were assessed using real-time polymerase chain reaction (PCR) and histological examination. Pre- treatment of rats with C. proximus decreased the ratio of heart weight to body weight and gene expression of hypertrophy markers atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and &beta

myosin heavy chain (&beta

MHC), which were induced by isoproterenol. Moreover, C. proximus prevented the increase in gene expression of fibrosis markers procollagen I and procollagen III and alleviated the collagen volume fraction caused by isoproterenol. The pre- treatment with C. proximus essential oil conferred cardio-protection against isoproterenol- induced cardiac hypertrophy and fibrosis.

Titel:	Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis
Autor/in / Beteiligte Person:	Faisal F Albaqami ; Abdel-Kader, Maged S. ; Hassan N Althurwi ; Alharthy, Khalid M. ; Mohamad ayman Abdulilah salkini
Link:	View record at OpenAIRE (Volltext) https://doi.org/10.3390/molecules25081786
Zeitschrift:	Molecules, Jg. 25 (2020-04-13), Heft 1786, p 1786, S. 1786-1786
Veröffentlichung:	MDPI AG, 2020
Medientyp:	unknown
ISSN:	1420-3049 (print)
DOI:	10.3390/molecules25081786
Schlagwort:	Male Cardiac fibrosis cardiac fibrosis Pharmaceutical Science Analytical Chemistry Muscle hypertrophy Cymbopogon proximus 0302 clinical medicine Atrial natriuretic peptide Fibrosis Natriuretic Peptide, Brain Drug Discovery Gene expression Myocytes, Cardiac 0303 health sciences biology cardiac hypertrophy Heart Brain natriuretic peptide Chemistry (miscellaneous) 030220 oncology & carcinogenesis cardiovascular system Molecular Medicine Atrial Natriuretic Factor Injections, Intraperitoneal Agonist medicine.medical_specialty medicine.drug_class Cardiomegaly Protective Agents Article Collagen Type I Gas Chromatography-Mass Spectrometry lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry Internal medicine Oils, Volatile medicine Animals Cymbopogon Physical and Theoretical Chemistry 030304 developmental biology Myosin Heavy Chains isoproterenol business.industry Myocardium Organic Chemistry medicine.disease biology.organism_classification Rats Collagen Type III Endocrinology cardiac remodeling business
Sonstiges:	Nachgewiesen in: OpenAIRE File Description: application/pdf Rights: OPEN

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