The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis
In: Science, Jg. 306 (2004-10-22), S. 695-698
Online
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Zugriff:
Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here we show that α4, a noncatalytic subunit of protein phosphatase 2A (PP2A), is required to repress apoptosis in murine cells. α4 is a nonredundant regulator of the dephosphorylation of the transcription factors c-Jun and p53. As a result of α4deletion, multiple proapoptotic genes were transcribed. Either inhibition of new protein synthesis or Bcl-xLoverexpression suppressed apoptosis initiated by α4deletion. Thus, mammalian cell viability depends on repression of transcription-initiated apoptosis mediated by a component of PP2A.
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The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis
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Autor/in / Beteiligte Person: | Fox, Casey J. ; Lindsten, Tullia ; Thompson, Craig B. ; Xu, Anne ; Kong, Mei ; Solt, Laura A. ; Cinalli, Ryan M. ; Mu, James ; Birnbaum, Morris J. |
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Zeitschrift: | Science, Jg. 306 (2004-10-22), S. 695-698 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 2004 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.1100537 |
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