Contribution of gene I polymorphism in conferring risk for essential hypertension: a case control study from South India
In: Journal of the Renin-Angiotensin-Aldosterone System, Jg. 14 (2013-09-01)
Online
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Zugriff:
Background: Renin is a rate-limiting enzyme of the renin–angiotensin–aldosterone system (RAAS) that plays a crucial role in the regulation of blood pressure. The renin gene has been suggested as a marker for genetic predisposition to essential hypertension (EHT) in humans. The purpose of the study is to explore the association of a genetic marker of renin gene Mbo I polymorphism with EHT in the South Indian population. Methods: A total of 279 hypertensive and 200 normotensive subjects were genotyped for REN Mbo I polymorphism (RFLP) using the PCR-restriction fragment length polymorphism method. Results: There were no significant differences in the distribution of genotypes and alleles for REN gene Mbo I polymorphism between hypertensive cases and controls ( p >0.05). The genotypic and allele frequencies were in Hardy–Weinberg equilibrium both in cases and controls. Females with Mbo I AA+GA genotypes had 1.87-fold higher risk to develop hypertension as compared with those with GG genotype (odds ratio 1.87; 95% confidence interval = 0.98–3.56, p = 0.057). Conclusions: Our results indicate that renin gene Mbo I site polymorphism is not associated with blood pressure levels and risk of hypertension. However, the present study demonstrates risk for females who are carriers of REN Mbo I A allele for developing essential hypertension.
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Contribution of gene I polymorphism in conferring risk for essential hypertension: a case control study from South India
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Autor/in / Beteiligte Person: | Padma, T. ; Swapna, N. ; Usha, G ; Vishnupriya, Satti ; U Mohana Vamsi |
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Zeitschrift: | Journal of the Renin-Angiotensin-Aldosterone System, Jg. 14 (2013-09-01) |
Veröffentlichung: | Hindawi - SAGE Publishing, 2013 |
Medientyp: | unknown |
ISSN: | 1752-8976 (print) ; 1470-3203 (print) |
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