Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue
In: Biochemical and Biophysical Research Communications, Jg. 572 (2021-10-01), S. 92-97
Online
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Zugriff:
Brown adipose tissue (BAT) is an anti-obese and anti-diabetic tissue that stimulates energy expenditure in the form of adaptive thermogenesis through uncoupling protein 1 (UCP1). Mitogen-inducible gene-6 (Mig-6) is a negative regulator of epidermal growth factor receptor (EGFR) that interacts with many cellular partners and has multiple cellular functions. We have recently reported that Mig-6 is associated with diabetes and metabolic syndrome. However, its function in BAT is unknown. We generated a brown adipocyte-specific Mig-6 knock-in mouse (BKI) to examine the role of Mig-6 in BAT. Mig-6 BKI mice had improved glucose tolerance on a normal chow diet. Mig-6 BKI mice also revealed activated thermogenesis and the size of the BAT lipid droplets was reduced. Additionally, Mig-6 regulated cAMP-PKA signaling-induced UCP1 expression in brown adipocytes. Taken together, these results demonstrate that Mig-6 affects glucose tolerance and thermogenesis in BAT.
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Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue
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Autor/in / Beteiligte Person: | Jae Wook Jeong ; Kyong Hye Joung ; Kim, Hyun-Jin ; Choung, Sorim ; Seon Mee Kang ; Ji Min Kim ; Bon Jeong Ku |
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Zeitschrift: | Biochemical and Biophysical Research Communications, Jg. 572 (2021-10-01), S. 92-97 |
Veröffentlichung: | Elsevier BV, 2021 |
Medientyp: | unknown |
ISSN: | 0006-291X (print) |
DOI: | 10.1016/j.bbrc.2021.07.088 |
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