Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension
In: Hypertension (Dallas, Tex. : 1979), Jg. 38 (2001-08-18), Heft 2
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Zugriff:
An ouabain-like factor has been implicated repeatedly in salt-sensitive hypertension as a natriuretic agent. However, the response of plasma ouabain-like factor to acute and chronic variation of body sodium is unclear. We studied 138 patients with essential hypertension who underwent an acute volume expansion/contraction maneuver (2 days) and 20 patients who entered a blind randomized crossover design involving chronically controlled sodium intake and depletion (170 to 70 mmol/d; 2 weeks each period). In both studies, plasma levels of ouabain-like factor were higher during sodium depletion (acute: 338.8±17.4 and 402.7±22.8 pmol/L for baseline and low sodium, respectively, P P =0.01). No significant change in plasma ouabain-like factor was observed after a 2-hour saline infusion (333.4±23.9 pmol/L) or controlled sodium (402.1±34.9 pmol/L). When patients were divided into salt-sensitive or salt-resistant groups, no differences in plasma ouabain-like factor were observed in the 2 groups at baseline or in response to the 2 protocols: salt resistant (n=69, 340.1±25.9 pmol/L) versus salt sensitive (n=69, 337.4±23.6 pmol/L) and chronic salt resistant (n=11, 336.0±53.2) versus salt sensitive (n=9, 301.1±331.4 pmol/L). However, circulating ouabain-like factor was increased by sodium depletion in both groups. These results demonstrate that circulating ouabain-like factor is raised specifically by maneuvers that promote the loss of body sodium. Acute expansion of body fluids with isotonic saline is not a stimulus to plasma ouabain-like factor. Moreover, basal levels of plasma ouabain-like factor do not differ among patients with salt-sensitive or salt-resistant hypertension. Taken together, these new results suggest that ouabain-like factor is involved in the adaptation of humans to sodium depletion and argue against the hypothesis that ouabain-like factor is a natriuretic hormone.
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Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension
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Autor/in / Beteiligte Person: | Manunta, P ; Messaggio, E ; Ballabeni, C ; Sciarrone, MT ; Lanzani, C ; Ferrandi, M ; Hamlyn, JM ; Cusi, D ; Bianchi, G ; Salt Sensitivity Study Group of the Italian Society of Hypertension ; GALLETTI, FERRUCCIO ; Sciarrone, Mt ; Hamlyn, Jm ; Galletti, Ferruccio ; Salt Sensitivity Study Group of the Italian Society of, Hypertension ; Manunta, Paolo ; Galletti, F ; SALT SENSITIVITY STUDY GROUP OF THE ITALIAN SOCIETY OF, Hypertension |
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Zeitschrift: | Hypertension (Dallas, Tex. : 1979), Jg. 38 (2001-08-18), Heft 2 |
Veröffentlichung: | 2001 |
Medientyp: | unknown |
ISSN: | 1524-4563 (print) |
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