The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma
In: Cell Reports, Jg. 14 (2016), Heft 6, S. 1488-1499
Online
unknown
Zugriff:
SummaryHow MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-B cells in pre-cancerous Eμ-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Eμ-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells.
| Titel: |
The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma
|
|---|---|
| Autor/in / Beteiligte Person: | Tarlinton, David M. ; Kelly, Gemma L. ; Jurado, Sabine ; Strasser, Andreas ; King, Ashleigh ; Walkley, Carl R. ; Wong, David M. ; Mannu K Walia ; Heierhorst, Joerg ; Wall, Meaghan ; Li, Lingli ; Bamford, Rebecca |
| Link: | |
| Zeitschrift: | Cell Reports, Jg. 14 (2016), Heft 6, S. 1488-1499 |
| Veröffentlichung: | Elsevier BV, 2016 |
| Medientyp: | unknown |
| ISSN: | 2211-1247 (print) |
| DOI: | 10.1016/j.celrep.2016.01.012 |
| Schlagwort: |
|
| Sonstiges: |
|