Chemical composition and biological activities of essential oil ofBeilschmiedia pulverulenta
In: Pharmaceutical Biology, Jg. 54 (2015-04-16), S. 322-330
Online
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Zugriff:
The ethnopharmacological study of Beilschmiedia indicates that several species are used for the treatment of various ailments.This is the first study of the chemical composition of Beilschmiedia pulverulenta Kosterm (Lauraceae) essential oil and its antioxidant, antimicrobial, antityrosinase, anti-inflammatory, and anticholinesterase activities.The antioxidant activities were evaluated by β-carotene, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric-reducing antioxidant power (FRAP), and phenolic content at different concentrations. The antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi were revealed by disk diffusion and microdilution. The antityrosinase and anti-inflammatory activities were assayed against mushroom tyrosinase and lipoxygenase enzymes. The anticholinesterase activity was analyzed using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.Forty-two components were detected in B. pulverulenta oil with eugenol (45.3%) being the major component. The oil phenolic content and the FRAP were 660.1 mg gallic acid/g and 604.0 mg ascorbic acid/g, respectively. The oil gave an IC50 value of 94.5 µg/mL and an inhibition of 93.9% in DPPH and β-carotene, respectively. The antimicrobial activity showed that the oil had strong activity against all Gram-positive bacteria with an minimum inhibitory concentration (MIC) value each of 62.5 µg/mL and moderate against all fungi with MIC and minimum bactericidal concentration (MBC) values each of 125 µg/mL. The oil showed significant antityrosinase and anti-inflammatory activities with 67.6 and 62.5% inhibition, respectively. In addition, the oil had moderate AChE (56.5%) and BChE (48.2%) activities.The results show that the oil could potentially be used for nutraceutical industries, food manufactures, and therapeutic agents against various diseases such as inflammation and rheumatism.
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Chemical composition and biological activities of essential oil ofBeilschmiedia pulverulenta
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Autor/in / Beteiligte Person: | Razauden Mohamed Zulkifli ; Wan Mohd Nuzul Hakimi Wan Salleh ; Khong Heng Yen ; Ahmad, Farediah |
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Zeitschrift: | Pharmaceutical Biology, Jg. 54 (2015-04-16), S. 322-330 |
Veröffentlichung: | Informa UK Limited, 2015 |
Medientyp: | unknown |
ISSN: | 1744-5116 (print) ; 1388-0209 (print) |
DOI: | 10.3109/13880209.2015.1037003 |
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