Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 171 (2003-12-10), Heft 12
Online
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Zugriff:
Recent studies have shown that CD4+ T cell help is required for the generation of memory CD8+ T cells that can proliferate and differentiate into effector cells on Ag restimulation. The importance of help for primary CD8+ T cell responses remains controversial. It has been suggested that help is not required for the initial proliferation and differentiation of CD8+ T cells in vivo and that classical models of helper-dependent responses describe impaired secondary responses to Ag in vitro. We have measured primary CD8+ T cell responses to peptide-pulsed dendritic cells in mice by cytokine ELISPOT and tetramer staining. No responses were detected in the absence of help, either when normal dendritic cells were injected into MHC II-deficient mice or when MHC II-deficient dendritic cells were injected into normal mice. Thus, the primary in vivo CD8+ T cell response depends absolutely on help from CD4+ T cells in our experimental system.
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Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo
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Autor/in / Beteiligte Person: | Wang, Jyh-Chiang E. ; Livingstone, Alexandra M. |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 171 (2003-12-10), Heft 12 |
Veröffentlichung: | 2003 |
Medientyp: | unknown |
ISSN: | 0022-1767 (print) |
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