Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity
In: Frontiers in Immunology, Jg. 13 (2022-09-16)
Online
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Zugriff:
Cytotoxic CD8 T cells are crucial for the host antigen-specific immune response to viral pathogens. Here we report the identification of an essential role for the serine/arginine-rich splicing factor (SRSF) 1 in CD8 T cell homeostasis and function. Specifically, SRSF1 is necessary for the maintenance of normal CD8 T lymphocyte numbers in the lymphoid compartment, and for the proliferative capacity and cytotoxic function of CD8 T cells. Furthermore, SRSF1 is required for antigen-specific IFN-γ cytokine responses in a viral infection challenge in mice. Transcriptomics analyses of Srsf1-deficient T cells reveal that SRSF1 controls proliferation, MAP kinase signaling and IFN signaling pathways. Mechanistically, SRSF1 controls the expression and activity of the Mnk2/p38-MAPK axis at the molecular level. Our findings reveal previously unrecognized roles for SRSF1 in the physiology and function of cytotoxic CD8 T lymphocytes and a potential molecular mechanism in viral immunopathogenesis.
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Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity
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Autor/in / Beteiligte Person: | Ignacio, Juarez ; Shi, Su ; Zachary T, Herbert ; John R, Teijaro ; Vaishali R, Moulton |
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Zeitschrift: | Frontiers in Immunology, Jg. 13 (2022-09-16) |
Veröffentlichung: | Frontiers Media SA, 2022 |
Medientyp: | unknown |
ISSN: | 1664-3224 (print) |
DOI: | 10.3389/fimmu.2022.906355 |
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