Essential role for TRPC5 in amygdala function and fear-related behavior
In: Cell, Jg. 137 (2008-06-24), Heft 4
Online
unknown
Zugriff:
SUMMARY The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel subunits. These excitatory, nonselective cationic channels are regulated by G protein, phospholipase C-coupled receptors. Here, we show that TRPC5 � /� mice exhibit diminished innate fear levels in response to innately aversive stimuli. Moreover, mutant mice exhibited significant reductions in responses mediated by synaptic activation of Group I metabotropic glutamate and cholecystokinin 2 receptors in neurons of the amygdala. Synaptic strength at afferent inputs to the amygdala was diminished in P10-P13 null mice. In contrast, baseline synaptic transmission, membrane excitability, and spike timing-dependent long-term potentiation at cortical and thalamic inputs to the amygdala were largely normal in older null mice. These experiments provide genetic evidence that TRPC5, activated via G protein-coupled neuronal receptors, has an essential function in innate fear.
Titel: |
Essential role for TRPC5 in amygdala function and fear-related behavior
|
---|---|
Autor/in / Beteiligte Person: | Tsvetkov, Evgeny ; Riccio, Antonio ; Gapon, Svetlana ; Smith, Kiersten S. ; Gui Lan Yao ; Moon, Jisook ; Bolshakov, Vadim Y. ; Li, Yan ; Rudolph, Uwe ; Ashlee Van't Veer ; Rodig, Scott J. ; Kim, Kwang-Soo ; Clapham, David E. ; Meloni, Edward G. ; Carlezon, William A. |
Link: | |
Zeitschrift: | Cell, Jg. 137 (2008-06-24), Heft 4 |
Veröffentlichung: | 2008 |
Medientyp: | unknown |
ISSN: | 1097-4172 (print) |
Schlagwort: |
|
Sonstiges: |
|