Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region

Sirithunyalug, Jakkapan ; Laothaweerungsawat, Natnaree ; et al.

In: Molecules, Jg. 25 (2020-03-01), Heft 5, p 1101

Online unknown

Zugriff:

Origanum vulgare L. has been used as a culinary ingredient worldwide. This study revealed the cosmeceutical potential of O. vulgare essential oil as a skin-ageing retardant. The O. vulgare essential oil from a highland area of a tropical country (HO), obtained by hydrodistillation was investigated and compared to a commercial oil from the Mediterranean region (CO). Their chemical compositions were investigated by gas chromatography&ndash

mass spectrometry. Antioxidant activities were investigated by ferric reducing antioxidant power, 1,1-diphenyl-2-picrylhydrazyl, and ferric thiocyanate assay. Anti-skin-ageing activities were determined by means of collagenase, elastase, and hyaluronidase inhibition. Carvacrol was the major component in both oils, but a higher amount was detected in HO (79.5%) than CO (64.6%). HO possessed comparable radical scavenging activity to CO (IC50 = 1.8 ±

0.8 mg/mL) but significantly higher lipid peroxidation inhibition (38.0 ±

0.8%). Carvacrol was remarked as the major compound responsible for the reducing power of both oils. Interestingly, HO possessed significant superior anti-skin-ageing activity than ascorbic acid (P <

0.01), with inhibition against collagenase, elastase, and hyaluronidase of 92.0 ±

9.7%, 53.1 ±

13.3%, and 16.7 ±

0.3%, at the concentration of 67, 25, and 4 µ

g/mL, respectively. Since HO possessed comparable anti-hyaluronidase activity to CO and superior anti-collagenase and anti-elastase (P <

0.01), HO was suggested to be used as a natural skin-ageing retardant in a cosmetic industry.

Titel:	Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region
Autor/in / Beteiligte Person:	Sirithunyalug, Jakkapan ; Laothaweerungsawat, Natnaree ; Chaiyana, Wantida
Link:	View record at OpenAIRE (Volltext)
Zeitschrift:	Molecules, Jg. 25 (2020-03-01), Heft 5, p 1101
Veröffentlichung:	Multidisciplinary Digital Publishing Institute, 2020
Medientyp:	unknown
ISSN:	1420-3049 (print)
DOI:	10.3390/molecules25051101
Schlagwort:	Antioxidant antioxidant medicine.medical_treatment anti-skin-ageing carvacrol Pharmaceutical Science hyaluronidase 01 natural sciences Analytical Chemistry law.invention Lipid peroxidation lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Ingredient lcsh:Organic chemistry law Hyaluronidase Drug Discovery medicine elastase Carvacrol Food science Physical and Theoretical Chemistry gas chromatography–mass spectrometry Essential oil 030304 developmental biology 0303 health sciences biology Chemistry Origanum vulgare Organic Chemistry Origanum biology.organism_classification Ascorbic acid 0104 chemical sciences collagenase 010404 medicinal & biomolecular chemistry Chemistry (miscellaneous) Molecular Medicine medicine.drug
Sonstiges:	Nachgewiesen in: OpenAIRE Sprachen: English File Description: application/pdf Language: English Rights: OPEN

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