Stat-1 is not essential for inhibition of B lymphopoiesis by type I IFNs
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 165 (2000-08-18), Heft 5
Online
unknown
Zugriff:
Type I IFNs, IFN-α, -β, and -ω, are cytokine family members with multiple immune response roles, including the promotion of cell growth and differentiation. Conversely, the type I IFNs are potent inhibitors of IL-7-dependent growth of early B lineage progenitors, effectively aborting further B lineage differentiation at the pro-B cell stage. Type I IFNs α and β function via receptor-mediated activation of a Jak/Stat signaling pathway in which Stat-1 is functionally important, because many IFN-induced responses are abrogated in Stat-1-deficient mice. To the contrary, we show here that the inhibition of IL-7-dependent B lymphopoiesis by IFN-αβ is unaffected in Stat-1-deficient mice. The present data indicate that the type I IFNs can activate an alternative signaling pathway in which neither Stat-1 nor phosphatidylinositol 3′-kinase are essential components.
Titel: |
Stat-1 is not essential for inhibition of B lymphopoiesis by type I IFNs
|
---|---|
Autor/in / Beteiligte Person: | Gongora, Rafael ; Stephan, Robert P. ; Robert D Schreiber ; Cooper, Max D. |
Link: | |
Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 165 (2000-08-18), Heft 5 |
Veröffentlichung: | 2000 |
Medientyp: | unknown |
ISSN: | 0022-1767 (print) |
Schlagwort: |
|
Sonstiges: |
|