Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor

Claesson, Marcus J. ; Palva, Airi ; et al.

In: Proceedings of the National Academy of Sciences of the United States of America 108 (2011) 27 Proceedings of the National Academy of Sciences of the United States of America, 108(27), 11217-11222 Proceedings of the National Academy of Sciences USA, 108, 11217-22 Proceedings of the National Academy of Sciences USA, 108, 27, pp. 11217-22

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Development of the human gut microbiota commences at birth, with bifidobacteria being among the first colonizers of the sterile newborn gastrointestinal tract. To date, the genetic basis of Bifidobacterium colonization and persistence remains poorly understood. Transcriptome analysis of the Bifidobacterium breve UCC2003 2.42-Mb genome in a murine colonization model revealed differential expression of a type IVb tight adherence (Tad) pilus-encoding gene cluster designated “ tad 2003 .” Mutational analysis demonstrated that the tad 2003 gene cluster is essential for efficient in vivo murine gut colonization, and immunogold transmission electron microscopy confirmed the presence of Tad pili at the poles of B. breve UCC2003 cells. Conservation of the Tad pilus-encoding locus among other B. breve strains and among sequenced Bifidobacterium genomes supports the notion of a ubiquitous pili-mediated host colonization and persistence mechanism for bifidobacteria.

Titel:	Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor
Autor/in / Beteiligte Person:	Claesson, Marcus J. ; Palva, Airi ; Reunanen, Justus ; Higgins, Des ; Casey, Pat G. ; Kearney, Breda ; O'Brien, Frances ; O'Toole, Paul W. ; Bottacini, Francesca ; Houston, Aileen ; Fitzgerald, Gerald F. ; Leahy, Sinead C. ; Zomer, Aldert ; Willem M. de Vos ; José Antonio Moreno Muñoz ; Flynn, Kiera ; Shanahan, Fergus ; Ventura, Marco ; Douwe van Sinderen ; O'Mahony, Caitlin ; Mary O'Connell Motherway
Link:	View record at OpenAIRE (Volltext) https://doi.org/10.1073/pnas.1105380108
Quelle:	Proceedings of the National Academy of Sciences of the United States of America 108 (2011) 27 Proceedings of the National Academy of Sciences of the United States of America, 108(27), 11217-11222 Proceedings of the National Academy of Sciences USA, 108, 11217-22 Proceedings of the National Academy of Sciences USA, 108, 27, pp. 11217-22
Veröffentlichung:	2011
Medientyp:	unknown
ISSN:	0027-8424 (print)
DOI:	10.1073/pnas.1105380108
Schlagwort:	Male ved/biology.organism_classification_rank.species insights Genome Pilus Transcriptome Mice fluids and secretions Microbiologie Gene cluster Colonization Microscopy, Immunoelectron genes Bifidobacterium actinobacillus-actinomycetemcomitans Genetics Comparative Genomic Hybridization Mice, Inbred BALB C Multidisciplinary Bifidobacterium breve health Biological Sciences gram-positive bacteria Multigene Family Female DNA, Bacterial Energy and redox metabolism [NCMLS 4] Molecular Sequence Data formula-fed infants Locus (genetics) Biology Microbiology digestive system Bacterial Proteins Microscopy, Electron, Transmission microbiota Animals Germ-Free Life Humans Amino Acid Sequence VLAG Base Sequence Sequence Homology, Amino Acid ved/biology Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] Gene Expression Regulation, Bacterial biology.organism_classification proteins Gastrointestinal Tract Fimbriae, Bacterial polysaccharide Mutation Metagenome identification bacteria Genome, Bacterial
Sonstiges:	Nachgewiesen in: OpenAIRE File Description: application/pdf; application/octet-stream Rights: OPEN

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