Airborne Antituberculosis Activity of Eucalyptus citriodora Essential Oil
In: Journal of Natural Products, Jg. 77 (2014-03-18), S. 603-610
Online
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Zugriff:
The rapid emergence of multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) has created a pressing public health problem, which mostly affects regions with HIV/AIDS prevalence and represents a new constraint in the already challenging disease management of tuberculosis (TB). The present work responds to the need to reduce the number of contagious MDR/XRD-TB patients, protect their immediate environment, and interrupt the rapid spread by laying the groundwork for an inhalation therapy based on anti-TB-active constituents of the essential oil (EO) of Eucalyptus citriodora. In order to address the metabolomic complexity of EO constituents and active principles in botanicals, this study applied biochemometrics, a 3-D analytical approach that involves high-resolution CCC fractionation, GC-MS analysis, bioactivity measurements, and chemometric analysis. Thus, 32 airborne anti-TB-active compounds were identified in E. citriodora EO: the monoterpenes citronellol (1), linalool (3), isopulegol (5), and α-terpineol (7) and the sesquiterpenoids spathulenol (11), β-eudesmol (23), and τ-cadinol (25). The impact of the interaction of multiple components in EOs was studied using various artificial mixtures (AMxs) of the active monoterpenes 1, 2, and 5 and the inactive eucalyptol (33). Both neat 1 and the AMx containing 1, 2, and 33 showed airborne TB inhibition of >90%, while the major E. citriodora EO component, 2, was only weakly active, at 18% inhibition.
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Airborne Antituberculosis Activity of Eucalyptus citriodora Essential Oil
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Autor/in / Beteiligte Person: | Pauli, Guido F. ; Franzblau, Scott G. ; René F. Ramos Alvarenga ; Jaki, Birgit U. ; Wan, Baojie ; Inui, Taichi |
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Zeitschrift: | Journal of Natural Products, Jg. 77 (2014-03-18), S. 603-610 |
Veröffentlichung: | American Chemical Society (ACS), 2014 |
Medientyp: | unknown |
ISSN: | 1520-6025 (print) ; 0163-3864 (print) |
DOI: | 10.1021/np400872m |
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