Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress
In: Cell reports Cell Reports Cell Reports, Jg. 17 (2016), Heft 7, S. 1882-1891
Online
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Zugriff:
Summary MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.
Graphical Abstract
Highlights • miR-15a levels are elevated in the amygdala-Ago2 complex following chronic stress • miR-15a targets FKBP51 and affects behavioral responses to stressful challenges • miR-15a is elevated in peripheral human blood following dexamethasone exposure • miR-15a is elevated in peripheral human blood of patients exposed to childhood trauma
Volk et al. reveal an important role for microRNA-15a in coping with chronic stress, with amygdala-specific manipulation affecting behavioral responses to stressful challenge. Individuals exposed to childhood trauma exhibit increased levels of miR-15a in their peripheral blood, suggesting a target for the treatment of stress-related psychopathologies.
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Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress
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Autor/in / Beteiligte Person: | Chen, Alon ; Binder, Elisabeth B. ; Cattane, Nadia ; Cattaneo, Annamaria ; Engel, Mareen ; Zannas, Anthony S. ; Volk, Naama ; Pape, Julius C. |
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Zeitschrift: | Cell reports Cell Reports Cell Reports, Jg. 17 (2016), Heft 7, S. 1882-1891 |
Veröffentlichung: | Elsevier BV, 2016 |
Medientyp: | unknown |
ISSN: | 2211-1247 (print) |
DOI: | 10.1016/j.celrep.2016.10.038 |
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