IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells
In: Science, Jg. 261 (1993-09-17), S. 1591-1594
Online
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Zugriff:
Although several interleukin-3 (IL-3)-dependent cell lines proliferate in response to IL-4 or insulin, the 32D line does not. Insulin and IL-4 sensitivity was restored to 32D cells by expression of IRS-1, the principal substrate of the insulin receptor. Although 32D cells possessed receptors for both factors, they lacked the IRS-1--related protein, 4PS, which becomes phosphorylated by tyrosine in insulin- or IL-4--responsive lines after stimulation. These results indicate that factors that bind unrelated receptors can use similar mitogenic signaling pathways in hematopoietic cells and that 4PS and IRS-1 are functionally similar proteins that are essential for insulin- and IL-4--induced proliferation.
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IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells
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Autor/in / Beteiligte Person: | White, Morris F. ; Xiao Jian Sun ; Myers, Martin G. ; Aaronson, Stuart A. ; Ling Mei Wang ; Pierce, Jacalyn H. |
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Zeitschrift: | Science, Jg. 261 (1993-09-17), S. 1591-1594 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 1993 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.8372354 |
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