Anti-inflammatory effect of L-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters
In: Amino acids, Jg. 53 (2021-04-12), Heft 9
Online
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Zugriff:
Oral mucositis is an inflammation of the oral mucosa mainly resulting from the cytotoxic effect of 5-fluorouracil (5-FU). The literature shows anti-inflammatory action of l-cysteine (l-cys) involving hydrogen sulfide (H2S). In view of these properties, we investigate the effect of l-cys in oral mucositis induced by 5-FU in hamsters. The animals were divided into the following groups: saline 0.9%, mechanical trauma, 5-FU 60–40 mg/kg, l-cys 10/40 mg and NaHS 27 µg/kg. 5-FU was administered on days 1st to 2nd; 4th day excoriations were made on the mucosa; 5th–6th received l-cys and NaHS. For data analysis, histological analyses, mast cell count, inflammatory and antioxidants markers, and immunohistochemistry (cyclooxygenase-2(COX-2)/inducible nitric oxide synthase (iNOs)/H2S) were performed. Results showed that l-cys decreased levels of inflammatory markers, mast cells, levels of COX-2, iNOS and increased levels of antioxidants markers and H2S when compared to the group 5-FU (p
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Anti-inflammatory effect of L-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters
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Autor/in / Beteiligte Person: | Jand Venes R. Medeiros ; Khetyma Moreira Fonseca ; Letícia de Sousa Chaves ; Jelson Lina de Carvalho ; Francisca Beatriz M. Sousa ; André Luis Fernandes Lopes ; Ana Patrícia de Oliveira ; Valderlon Freitas da Silva ; Lucas A.D. Nicolau ; Gilberto Santos Cerqueira ; Conceição da Silva Martins ; Dionys Macda RodriguesCosta |
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Zeitschrift: | Amino acids, Jg. 53 (2021-04-12), Heft 9 |
Veröffentlichung: | 2021 |
Medientyp: | unknown |
ISSN: | 1438-2199 (print) |
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