The poly(C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation
In: iScience, Jg. 26 (2023), S. 105860-105860
Online
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Zugriff:
The RNA-binding protein Pcbp2 is widely expressed in the innate and adaptive immune systems and is essential for mouse development. To determine whether Pcbp2 is required for CD4+ T cell development and function, we derived mice with conditional Pcbp2 deletion in CD4+ T cells and assessed their overall phenotype and proliferative responses to activating stimuli. We found that Pcbp2 is essential for T conventional cell (Tconv) proliferation, working through regulation of co-stimulatory signaling. Pcbp2 deficiency in the CD4+ lineage did not impact Treg abundance in vivo or function in vitro. In addition, our data demonstrate a clear association between Pcbp2 control of Runx1 exon 6 splicing in CD4+ T cells and a specific role for Pcbp2 in the maintenance of peripheral CD4+ lymphocyte population size. Last, we show that Pcbp2 function is required for optimal in vivo Tconv cell activation in a T cell adoptive transfer colitis model system.
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The poly(C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation
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Autor/in / Beteiligte Person: | Martinelli, Massimo ; Aguilar, Gabrielle ; David S.M. Lee ; Kromer, Andrew ; Nguyen, Nhu ; Wilkins, Benjamin J. ; Akimova, Tatiana ; Beier, Ulf H. ; Ghanem, Louis R. ; Lee, David S M ; Wilkins, Benjamin J ; Beier, Ulf H ; Ghanem, Louis R |
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Zeitschrift: | iScience, Jg. 26 (2023), S. 105860-105860 |
Veröffentlichung: | Elsevier BV, 2023 |
Medientyp: | unknown |
ISSN: | 2589-0042 (print) |
DOI: | 10.1016/j.isci.2022.105860 |
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