Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study
In: Journal of Neurology, Neurosurgery & Psychiatry, Jg. 92 (2021-04-27), S. 927-931
Online
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Zugriff:
BackgroundUnilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is efficacious for the treatment of medically refractory essential tremor (ET). Viability of bilateral FUS ablation is unexplored.MethodsPatients diagnosed with medically refractory ET and previously treated with unilateral FUS thalamotomy at least 5 months before underwent bilateral treatment. The timepoints were baseline (before first thalamotomy) and FUS1 and FUS2 (4 weeks before and 6 months after second thalamotomy, respectively). The primary endpoint was safety. Efficacy was assessed through the Clinical Rating Scale for Tremor (CRST), which includes subscales for tremor examination (part A), task performance (part B) and tremor-related disability (part C).ResultsNine patients were treated. No permanent adverse events were registered. Six patients presented mild gait instability and one dysarthria, all resolving within the first few weeks. Three patients reported perioral hypoesthesia, resolving in one case. Total CRST score improved by 71% from baseline to FUS2 (from 52.3±12 to 15.5±9.4, pConclusionBilateral staged FUS thalamotomy for ET is feasible and might be safe and effective. Voice and head tremor might also improve. A controlled study is warranted.
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Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study
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Autor/in / Beteiligte Person: | Hernández-Fernández, Frida ; Obeso, Ignacio ; Martínez-Fernández, Raúl ; Marta del Álamo ; Matarazzo, Michele ; Pineda-Pardo, José A. ; Jorge U Máñez-Miró ; Deuschl, Günther ; Obeso, Jose A. ; Rodriguez-Rojas, Rafael ; Stieglitz, Lennart ; Lain H Gonzalez-Quarante ; Werner, Beat ; Mahendran, Sujitha ; Baumann, Christian R. ; Imbach, Lukas L. ; Büchele, Fabian |
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Zeitschrift: | Journal of Neurology, Neurosurgery & Psychiatry, Jg. 92 (2021-04-27), S. 927-931 |
Veröffentlichung: | BMJ, 2021 |
Medientyp: | unknown |
ISSN: | 1468-330X (print) ; 0022-3050 (print) |
DOI: | 10.1136/jnnp-2020-325278 |
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