A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication
In: Journal of Virology, Jg. 62 (1988-02-01), S. 528-533
Online
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Zugriff:
The virion proteins encoded by the avian retroviral pol gene (reverse transcriptase and endonuclease) are formed by the proteolytic processing of a gag-pol fusion protein precursor. Recent studies have predicted that the avian sarcoma-leukosis virus pol precursor protein undergoes a previously undetected processing event resulting in the formation of common C termini for the endonuclease (pp32) and the beta subunit of reverse transcriptase (F. Alexander, J. Leis, D. A. Soltis, R. M. Crowl, W. Danho, M. S. Poonian, Y.-C. E. Pan, and A. M. Skalka, J. Virol. 61:534-542, 1987; D. Grandgenett, T. Quinn, P. J. Hippenmeyer, and S. Oroszlan, J. Biol. Chem. 260:8243-8249, 1985). This processing event removes 37 amino acids, thus defining a new pol domain. In this report, we present evidence that this C-terminal domain is translated as part of the gag-pol precursor but is not required for replication of the virus in tissue culture cells.
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A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication
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Autor/in / Beteiligte Person: | R A Katz ; A M Skalka |
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Zeitschrift: | Journal of Virology, Jg. 62 (1988-02-01), S. 528-533 |
Veröffentlichung: | American Society for Microbiology, 1988 |
Medientyp: | unknown |
ISSN: | 1098-5514 (print) ; 0022-538X (print) |
DOI: | 10.1128/jvi.62.2.528-533.1988 |
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