Essential Role of Stem Cell Factor Signaling in Primary Sensory Neuron Development
In: Developmental Neuroscience, Jg. 31 (2009), S. 202-211
Online
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Zugriff:
Here we show that stem cell factor (SCF) signaling through its receptor, c-kit, is essential for the development of c-kit-expressing small- and medium-diameter primary sensory neurons. We used the W mouse, which is c-kit deficient and has a perinatal lethal phenotype due to a naturally occurring point mutation in the c-kit gene. In c-kit-null newborn mice, 52.5% of substance P immunoreactive and 31.4% of calcitonin gene-related peptide (CGRP) immunoreactive small- and medium-diameter sensory neurons were absent, whereas large-diameter sensory neurons were unaffected. Equivalent deficits occurred during embryogenesis. There was neither a developmental delay nor degeneration of differentiated neurons. We thus conclude that, in the absence of SCF signaling, neural crest-derived progenitors do not differentiate into c-kit-expressing visceral and somatic afferent neurons.
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Essential Role of Stem Cell Factor Signaling in Primary Sensory Neuron Development
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Autor/in / Beteiligte Person: | Sieber-Blum, Maya ; Zhang, Zhi-Jian |
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Zeitschrift: | Developmental Neuroscience, Jg. 31 (2009), S. 202-211 |
Veröffentlichung: | S. Karger AG, 2009 |
Medientyp: | unknown |
ISSN: | 1421-9859 (print) ; 0378-5866 (print) |
DOI: | 10.1159/000193396 |
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