Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine exposure in patients with essential hypertension
In: Journal of Thrombosis and Thrombolysis, Jg. 51 (2020-11-21), S. 933-940
Online
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Zugriff:
The exact mechanism of the prothrombotic state of essential hypertension (EH) patients remains elusive. Our objective was to assess whether phosphatidylserine (PS) exposure on endothelial cells (ECs), platelets, and microparticles (MPs) can account for the hypercoagulability in EH patients. PS exposure on cells and MPs, mainly from platelets and ECs was analyzed with flow cytometry. Procoagulant activity (PCA) was evaluated by purified coagulation complex assays, clotting time, and fibrin turbidity. We found that EH patients exhibited elevated levels of PS+ platelets, serum-cultured ECs, MPs, endothelial-derived MPs and platelet-derived MPs compared to the controls (all P
| Titel: |
Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine exposure in patients with essential hypertension
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| Autor/in / Beteiligte Person: | Zhang, Xiaohui ; Song, Bin ; Wang, Ying ; Xu, Yang ; Tong, Dongxia ; Li, Jihe ; Liu, Yue ; Yin, Xinhua ; Chen, Fuyang ; Liu, Wenxiu ; Li, Yang ; Liu, Na |
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| Zeitschrift: | Journal of Thrombosis and Thrombolysis, Jg. 51 (2020-11-21), S. 933-940 |
| Veröffentlichung: | Springer Science and Business Media LLC, 2020 |
| Medientyp: | unknown |
| ISSN: | 1573-742X (print) ; 0929-5305 (print) |
| DOI: | 10.1007/s11239-020-02342-x |
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