Chemical composition and evaluation of antinociceptive activity of the essential oil of Stevia serrata Cav. from Guatemala
In: Natural product research, Jg. 33 (2017-11-14), Heft 4
Online
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Zugriff:
The composition and the antinociceptive activity of the essential oil of Stevia serrata Cav. from a population located in the west highlands of Guatemala were evaluated. A yield of 0.2% (w/w) of essential oil was obtained by hydrodistillation of the dried aerial parts of the plant. The essential oil analysed by GC-FID and GC-MS showed a high content of sesquiterpenoids, with chamazulene (60.1%) as the major component and 91.5% of the essential oil composition was identified. To evaluate antinociceptive activity in mice, the essential oil of S. serrata Cav. was administered as gavage, using three different doses. In the formalin test, the animals were pre-treated with oral doses of the essential oil before the administration of formalin. Oral administration of S. serrata Cav. essential oil produced a marked antinociceptive activity. Therefore, the plant could be domesticated as a source of essential oil rich in chamazulene for developing medicinal products.
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Chemical composition and evaluation of antinociceptive activity of the essential oil of Stevia serrata Cav. from Guatemala
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Autor/in / Beteiligte Person: | Thais Biondino Sardella Giorno ; Daniel Luiz Reis Simas ; Juan Francisco Pérez-Sabino ; Antonio Jorge Ribeiro da Silva ; Edwin Adolfo Taracena ; Bessie Evelyn Oliva-Hernández ; Max Samuel Mérida-Reyes ; Millena Santos Cordeiro ; Martínez-Arevalo, José V. ; Manuel Alejandro Muñoz-Wug ; Patricia Dias Fernandes |
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Zeitschrift: | Natural product research, Jg. 33 (2017-11-14), Heft 4 |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 1478-6427 (print) |
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