Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 177 (2006-10-24), Heft 9
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Zugriff:
Microbial infections induce the replacement of constitutive proteasomes by immunoproteasomes (I-proteasomes). I-proteasomes support efficient generation of MHC class I epitopes and influence immunodominance hierarchies of CD8+ T cells. Recently, the function of I-proteasomes in antimicrobial responses was challenged by showing that the lack of I-proteasomes has no effect on induction and function of lymphocytic choriomeningitis virus-specific CD8+ T cells. Here, we show that infection with Listeria monocytogenes rapidly induces I-proteasomes in nonlymphoid tissues, which leads to enhanced generation of protection relevant CD8+ T cell epitopes. I-proteasome-deficient mice (β5i−/− mice) exhibited normal frequencies of L. monocytogenes-specific CD8+ T cells. However, clearance of L. monocytogenes in liver but not spleen was significantly impaired in I-proteasome-deficient mice. In summary, our studies demonstrate that induction of I-proteasomes is required for CD8+ T cell-mediated elimination of L. monocytogenes from nonlymphoid but not lymphoid tissues.
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Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells
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Autor/in / Beteiligte Person: | Kloetzel, Peter-Michael ; Visekruna, Alexander ; Strehl, Britta ; Rieger, Melanie ; Textoris-Taube, Kathrin ; Kaufmann, Stefan H. E. ; Steinhoff, Ulrich ; Kuckelkorn, Ulrike ; Joeris, Thorsten |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 177 (2006-10-24), Heft 9 |
Veröffentlichung: | 2006 |
Medientyp: | unknown |
ISSN: | 0022-1767 (print) |
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