The SWI/SNF-like BAF Complex Is Essential for Early B Cell Development
In: The Journal of Immunology, Jg. 188 (2012-04-15), S. 3791-3803
Online
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Zugriff:
During the process of B cell development, transcription factors, such as E2A and Ebf1, have been known to play key roles. Although transcription factors and chromatin regulators work in concert to direct the expression of B lineage-specific genes, little is known about the involvement of regulators for chromatin structure during B lymphopoiesis. In this article, we show that deletion of Srg3/mBaf155, a scaffold subunit of the SWI/SNF-like BAF complex, in the hematopoietic lineage caused defects at both the common lymphoid progenitor stage and the transition from pre–pro-B to early pro-B cells due to failures in the expression of B lineage-specific genes, such as Ebf1 and Il7ra, and their downstream target genes. Moreover, mice that were deficient in the expression of Brg1, a subunit of the complex with ATPase activity, also showed defects in early B cell development. We also found that the expression of Ebf1 and Il7ra is directly regulated by the SWI/SNF-like BAF complex. Thus, our results suggest that the SWI/SNF-like BAF complex facilitates early B cell development by regulating the expression of B lineage-specific genes.
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The SWI/SNF-like BAF Complex Is Essential for Early B Cell Development
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Autor/in / Beteiligte Person: | Kyung Soo Park ; Choi, Jinwook ; Rho Hyun Seong ; Yoon Kyung Jeon ; Lee, Ho ; Ko, Myunggon ; Lee, Changjin ; Jeon, Shin |
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Zeitschrift: | The Journal of Immunology, Jg. 188 (2012-04-15), S. 3791-3803 |
Veröffentlichung: | The American Association of Immunologists, 2012 |
Medientyp: | unknown |
ISSN: | 1550-6606 (print) ; 0022-1767 (print) |
DOI: | 10.4049/jimmunol.1103390 |
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