IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity
In: Frontiers in Immunology, Jg. 9 (2018-06-04)
Online
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Zugriff:
Identifying molecules that are differentially expressed in encephalitogenic T cells is critical to the development of novel and specific therapies for multiple sclerosis (MS). In this study, IL-3 was identified as a molecule highly expressed in encephalitogenic Th1 and Th17 cells, but not in myelin-specific non-encephalitogenic Th1 and Th17 cells. However, B10.PL IL-3-deficient mice remained susceptible to experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Furthermore, B10.PL myelin-specific T cell receptor transgenic IL-3−/− Th1 and Th17 cells were capable of transferring EAE to wild-type mice. Antibody neutralization of IL-3 produced by encephalitogenic Th1 and Th17 cells failed to alter their ability to transfer EAE. Thus, IL-3 is highly expressed in myelin-specific T cells capable of inducing EAE compared to activated, non-encephalitogenic myelin-specific T cells. However, loss of IL-3 in encephalitogenic T cells does not reduce their pathogenicity, indicating that IL-3 is a marker of encephalitogenic T cells, but not a critical element in their pathogenic capacity.
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IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity
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Autor/in / Beteiligte Person: | Lee, Priscilla W. ; Lovett-Racke, Amy E. ; Xin, Matthew K. ; Pei, Wei ; Yang, Yuhong |
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Zeitschrift: | Frontiers in Immunology, Jg. 9 (2018-06-04) |
Veröffentlichung: | Frontiers Media SA, 2018 |
Medientyp: | unknown |
ISSN: | 1664-3224 (print) |
DOI: | 10.3389/fimmu.2018.01255 |
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