WASp Is Essential for Effector-to-Memory conversion and for Maintenance of CD8+T Cell Memory
In: Frontiers in Immunology, Jg. 10 (2019-09-01)
Online
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Zugriff:
Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency characterized by recurrent infections, micro thrombocytopenia, eczema, and a high incidence of autoimmunity and malignancy. A defect in the T cell compartment is thought to be a major cause of immunodeficiency in patients with WAS; However, whether the antigen specific T memory cell is altered has not been extensively studied. Here, we examined the expansion/contraction kinetics of CD8+ memory T cells and their maintenance in WASp-/- mice. The results showed that WAS protein (WASp) is not required for differentiation of CD8+ effector T cells; however, CD8+ T cells from WASp-/- mice were hyperactive, resulting in increased cytokine production. The number of CD8+ T memory cells decreased as mice aged, and CD8+ T cell recall responses and protective immunity were impaired. WASp-deficient CD8+ T cells in bone marrow chimeric mice underwent clonal expansion, but the resulting effector cells failed to survive and differentiate into CD8+ memory T cells. Taken together, these findings indicate that WASp plays an intrinsic role in differentiation of CD8+ memory T cells.
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WASp Is Essential for Effector-to-Memory conversion and for Maintenance of CD8+T Cell Memory
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Autor/in / Beteiligte Person: | Liu, Qiao ; Zhang, Liang ; Shu, Zhou ; Yu, Tingting ; Zhou, Lina ; Song, Wenxia ; Zhao, Xiaodong |
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Zeitschrift: | Frontiers in Immunology, Jg. 10 (2019-09-01) |
Veröffentlichung: | Frontiers Media S.A., 2019 |
Medientyp: | unknown |
ISSN: | 1664-3224 (print) |
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