Antidepressant-like effect of Cuminum cyminum essential oil on the forced swim and tail suspension tests in male mice
In: Journal of Shahrekord University of Medical Sciences, Jg. 22 (2020), Heft 4, S. 167-172
Online
unknown
Zugriff:
Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), including analgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study evaluated the antidepressant-like effects of the CC essential oil (EO) on the forced swim test (FST) and tail suspension test (TST) in male mice. Materials and Methods: The gas chromatography-mass spectrometry (GC-MS) apparatus was used for detecting the chemical compounds of CC EO. In the present study, 72 male NMRI mice were randomly allocated to 12 groups (each containing 6 animals) including control or vehicle (10 mL/kg, i.p.), fluoxetine (20 mg/kg, i.p.), imipramine (30 mg/kg, i.p), and the CC EO (100, 200, and 300 mg/kg, i.p.). Then, several parameters were measured and recorded, including immobility time, swimming time, and climbing time in FST, along with immobility time in TST, respectively. Results: Cuminaldehyde followed by cymene, γ-terpinene, phenylglycol, 2-caren-10-al, 2-β-pinene, acoradiene, and cuminic acid were the major components of the CC EO. Based on the results, all doses of the CC, fluoxetine, and imipramine reduced immobility time in both FST (P
Titel: |
Antidepressant-like effect of Cuminum cyminum essential oil on the forced swim and tail suspension tests in male mice
|
---|---|
Autor/in / Beteiligte Person: | Asadi, Kosar ; Abbasi-Maleki, Saeid ; Goudarz Sadeghi Hashjin |
Link: | |
Zeitschrift: | Journal of Shahrekord University of Medical Sciences, Jg. 22 (2020), Heft 4, S. 167-172 |
Veröffentlichung: | Shahrekord University of Medical Sciences, 2020 |
Medientyp: | unknown |
ISSN: | 2717-0071 (print) |
Schlagwort: |
|
Sonstiges: |
|