An essential role for calmodulin in regulating human T cell aggregation
In: FEBS Letters, Jg. 491 (2001-02-20), S. 131-136
Online
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Zugriff:
After activation of T cells with either CD3 antibodies or phorbol esters, we have found that T cell–cell aggregation, integrin-dependent actin reorganisation and cell spreading are strongly suppressed by any of three structurally different calmodulin antagonists, without any effect on the amount of CD11/CD18 integrin binding to the actin cytoskeleton. However, only T cell receptor-induced, and not phorbol ester-induced, aggregation and cell spreading are prevented by inhibitors of phosphatidylinositide (PI) 3-kinase. These results suggest that PI 3-kinase lies upstream of calmodulin in the signalling pathway leading to T cell aggregation, cell spreading and actin reorganisation and that cell spreading and actin reorganisation are essential for T cell adhesion.
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An essential role for calmodulin in regulating human T cell aggregation
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Autor/in / Beteiligte Person: | Cohen, Philip ; Prescott, Alan R. ; Fagerholm, Susanna C. ; Gahmberg, Carl G. |
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Zeitschrift: | FEBS Letters, Jg. 491 (2001-02-20), S. 131-136 |
Veröffentlichung: | Wiley, 2001 |
Medientyp: | unknown |
ISSN: | 0014-5793 (print) |
DOI: | 10.1016/s0014-5793(01)02182-2 |
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