Essential Immunoregulatory Role for BCAP in B Cell Development and Function
In: Journal of Experimental Medicine, Jg. 195 (2002-02-25), S. 535-545
Online
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Zugriff:
BCAP was recently cloned as a binding molecule to phosphoinositide 3-kinase (PI3K). To investigate the role of BCAP, mutant mice deficient in BCAP were generated. While BCAP-deficient mice are viable, they have decreased numbers of mature B cells and B1 B cell deficiency. The mice produce lower titers of serum immunoglobulin (Ig)M and IgG3, and mount attenuated responses to T cell–independent type II antigen. Upon B cell receptor cross-linking, BCAP-deficient B cells exhibit reduced Ca2+ mobilization and poor proliferative responses. These findings demonstrate that BCAP plays a pivotal immunoregulatory role in B cell development and humoral immune responses.
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Essential Immunoregulatory Role for BCAP in B Cell Development and Function
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Autor/in / Beteiligte Person: | Akira, Shizuo ; Takeshima, Hiroshi ; Takeda, Kiyoshi ; Gotoh, Kumiko ; Kurosaki, Tomohiro ; Yamazaki, Tetsuo |
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Zeitschrift: | Journal of Experimental Medicine, Jg. 195 (2002-02-25), S. 535-545 |
Veröffentlichung: | Rockefeller University Press, 2002 |
Medientyp: | unknown |
ISSN: | 1540-9538 (print) ; 0022-1007 (print) |
DOI: | 10.1084/jem.20011751 |
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