IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
In: Science, Jg. 278 (1997-10-31), S. 860-866
Online
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Zugriff:
Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is controlled by sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IkappaB. A large multiprotein complex, the IkappaB kinase (IKK) signalsome, was purified from HeLa cells and found to contain a cytokine-inducible IkappaB kinase activity that phosphorylates IkappaB-alpha and IkappaB-beta. Two components of the IKK signalsome, IKK-1 and IKK-2, were identified as closely related protein serine kinases containing leucine zipper and helix-loop-helix protein interaction motifs. Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway.
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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
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Autor/in / Beteiligte Person: | Mann, Matthias ; Jian Wu Li ; Barbosa, Miguel ; Mercurio, Frank ; Rao, Anjana ; Young, David B. ; Manning, Anthony M. ; Murray, Brion W. ; Bennett, Brydon L. ; Zhu, Hengyi ; Shevchenko, Andrej |
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Zeitschrift: | Science, Jg. 278 (1997-10-31), S. 860-866 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 1997 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.278.5339.860 |
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