Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
In: Immunity, Jg. 33 (2010-03-22), Heft 2
Online
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Zugriff:
Summary Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that IRF4 is also crucial for the development and function of an interleukin-9 (IL-9)-producing CD4 + T cell subset designated Th9. IRF4-deficient CD4 + T cells failed to develop into IL-9-producing Th9 cells, and IRF4-specific siRNA inhibited IL-9 production in wild-type CD4 + T cells. Chromatin-immunoprecipitation (ChIP) analyses revealed direct IRF4 binding to the Il9 promoter in Th9 cells. In a Th9-dependent asthma model, neutralization of IL-9 substantially ameliorated asthma symptoms. The relevance of these findings is emphasized by the fact that the induction of IL-9 production also occurs in human CD4 + T cells accompanied by the upregulation of IRF4. Our data clearly demonstrate the central function of IRF4 in the development of Th9 cells and underline the contribution of this T helper cell subset to the pathogenesis of asthma.
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Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
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Autor/in / Beteiligte Person: | Reuter, Sebastian ; Lingnau, Karen ; Klein, Matthias ; Bopp, Tobias ; Staudt, Valérie ; Becker, Marc ; Steinborn, Andrea ; Ulges, Alexander ; Grebe, Nadine ; Stassen, Michael ; Schmitt, Edgar ; Schild, Hansjörg ; Bothur, Evita ; Hoffmann, Markus ; Taube, Christian ; Gerlitzki, Bastian ; Lohoff, Michael ; Dehzad, Nina |
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Zeitschrift: | Immunity, Jg. 33 (2010-03-22), Heft 2 |
Veröffentlichung: | 2010 |
Medientyp: | unknown |
ISSN: | 1097-4180 (print) |
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