Oral Supplementation Effect of Iron and its Complex Form With Quercetin on Oxidant Status and on Redistribution of Essential Metals in Organs of Streptozotocin Diabetic Rats
In: Romanian Journal of Diabetes Nutrition and Metabolic Diseases, Jg. 26 (2019), Heft 1, S. 39-53
Online
unknown
Zugriff:
Background and aims: Quercetin, is a polyphenolic antioxidant compound. It is able to form complex with metal ions such as iron and exerts a broad range of biological activities like improving metabolic disorders. This research aims at investigating the effect of oral supplementation of iron (2.5mg Fe/Kg/day) and its complex form (molar ratio 1:5; 2.5mg/25mg/Kg/day) with quercetin (25mg/Kg/day) on lipid metabolism, oxidant status and trace elements contents in organs of Wistar diabetic rats (45 mg/kg/rat.ip of streptozotocin) during eight weeks of experimentation. Material and method: To achieve this, liver and adipose tissue enzymes activities, NO • , O2 −• , TBARs, carbonyl protein levels in plasma were analysed. Metals (Cu, Fe, Mg, Zn) analysis of organs were determined by inductively coupled plasma atomic emission spectroscopy. Results: Iron supplemented alone induced a noticeable disorder in lipid, lipoprotein, lipases and oxidant status. Yet, it caused an imbalance in the redistribution of metals in the organs of diabetic and non diabetic rats. Iron-quercetin complex was shown as less harmful and more beneficial than iron supplemented alone. Conclusions: This complex could reverse oxidative stress and iron deficiency mostly caused by the diabetic disease but at the same time it induces an imbalance in redistribution of other essential metals.
Titel: |
Oral Supplementation Effect of Iron and its Complex Form With Quercetin on Oxidant Status and on Redistribution of Essential Metals in Organs of Streptozotocin Diabetic Rats
|
---|---|
Autor/in / Beteiligte Person: | Belhandouz, Amina ; Boos, Anne ; Elhabiri, Mourad ; Merzouk, Hafida ; Berroukeche, Farid ; Ronot, Pascale ; Imessaoudene, Asmahan ; Ahmed Sabri Cherrak ; Mokhtari-Soulimane, Nassima ; Laboratoire de physiologie, physiopathologie, biochimie de la nutrition (Université d'Aboubekr Belkaid Tlemcen) ; Université Aboubekr Belkaid - University of Belkaïd Abou Bekr [Tlemcen] ; Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC) ; Institut Pluridisciplinaire Hubert Curien (IPHC) ; Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) ; Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) ; Université Tahri Mohamed Bechar [Bechar] ; Substances naturelles/chimie moléculaire ; Université Louis Pasteur - Strasbourg I-Ecole européenne de chimie, polymères et matériaux [Strasbourg]-Centre National de la Recherche Scientifique (CNRS) ; Laboratoire de chimie moléculaire (LCM) ; Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) ; Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) ; Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
Link: | |
Zeitschrift: | Romanian Journal of Diabetes Nutrition and Metabolic Diseases, Jg. 26 (2019), Heft 1, S. 39-53 |
Veröffentlichung: | Sciendo, 2019 |
Medientyp: | unknown |
ISSN: | 2284-6417 (print) ; 2068-8245 (print) |
Schlagwort: |
|
Sonstiges: |
|