5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein
In: Biochemical Journal, Jg. 278 (1991-08-15), S. 163-169
Online
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Zugriff:
The concentration-dependent effects of a series of lipoxygenase inhibitors and antioxidants on the macrophage-mediated oxidative modification of low-density lipoprotein (LDL) were measured. Their influence on macrophage 5-lipoxygenase pathway activity was also studied over the same concentration range. No correlation between inhibition of 5-lipoxygenase and of macrophage-mediated oxidation of LDL was observed. The capacity of the compounds to prevent cell-mediated modification of LDL could be explained in terms of their activity as either aqueous- or lipid-peroxyl radical scavengers. Two potent 5-lipoxygenase inhibitors (MK 886 and Revlon 5901), which had no radical-scavenging properties, were unable to block LDL modification. It is concluded that 5-lipoxygenase is not essential for LDL oxidation by macrophages.
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5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein
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Autor/in / Beteiligte Person: | Darley-Usmar, Victor M. ; Bedwell, S ; Jessup, Wendy ; O'Leary, Vanessa J. |
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Zeitschrift: | Biochemical Journal, Jg. 278 (1991-08-15), S. 163-169 |
Veröffentlichung: | Portland Press Ltd., 1991 |
Medientyp: | unknown |
ISSN: | 1470-8728 (print) ; 0264-6021 (print) |
DOI: | 10.1042/bj2780163 |
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