Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Ma, Haiyan ; Wu, Yinyin ; et al.

In: PloS one, Jg. 12 (2016-12-20), Heft 5

Online unknown

Zugriff:

Background and objective Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility. Methods One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models. Results Significant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P

Titel:	Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis
Autor/in / Beteiligte Person:	Ma, Haiyan ; Wu, Yinyin ; Lian, Fuzhi ; Ni, Juntao ; Yang, Lei ; Xu, Liangwen ; Cai, Xiao
Link:	View record at OpenAIRE (Volltext) https://pubmed.ncbi.nlm.nih.gov/28472173
Zeitschrift:	PloS one, Jg. 12 (2016-12-20), Heft 5
Veröffentlichung:	2016
Medientyp:	unknown
ISSN:	1932-6203 (print)
Schlagwort:	0301 basic medicine Male Heredity lcsh:Medicine Blood Pressure Artificial Gene Amplification and Extension 030204 cardiovascular system & hematology Essential hypertension Gastroenterology Vascular Medicine Polymerase Chain Reaction Geographical Locations 0302 clinical medicine Mathematical and Statistical Techniques Genotype Medicine and Health Sciences lcsh:Science education.field_of_study Multidisciplinary Alcohol Consumption Aldehyde Dehydrogenase, Mitochondrial Genetic Mapping Research Design Meta-analysis Hypertension Physical Sciences Female Statistics (Mathematics) Research Article medicine.medical_specialty China Asia Population Variant Genotypes Research and Analysis Methods Polymorphism, Single Nucleotide 03 medical and health sciences Internal medicine medicine Genetics Humans Genetic Predisposition to Disease Allele Statistical Methods education Molecular Biology Techniques Molecular Biology Nutrition Evolutionary Biology Population Biology business.industry lcsh:R Case-control study Biology and Life Sciences Odds ratio medicine.disease Confidence interval Diet 030104 developmental biology Case-Control Studies People and Places Genetic Polymorphism lcsh:Q business Mathematics Population Genetics Meta-Analysis
Sonstiges:	Nachgewiesen in: OpenAIRE Rights: OPEN

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