TCR signals mediated by Src family kinases are essential for the survival of naive T cells
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 169 (2002-09-10), Heft 6
Online
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Zugriff:
The role of TCR signals triggered by recognition of self MHCs in maintaining the survival of naive peripheral T cells remains controversial. Here we examine the role of the Src family kinases, p56lck (Lck) and p59fyn (Fyn), in the survival of naive T cells. We show that long term survival requires a combination of signals transduced by Src family kinases and signals through the IL-7R. In the absence of either one, naive T cells die slowly, but if both signals are removed, cell loss is greatly accelerated. The TCR signal can be mediated by either Fyn or Lck at wild-type levels of expression, but not by Lck alone if expressed suboptimally. The disappearance of T cells in the absence of Fyn and Lck was associated with a complete loss of TCRζ-chain phosphorylation and down-regulation of CD5, both of which are also MHC contact dependent, indicating that the Src family kinases are critical for transducing a TCR-MHC survival signal.
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TCR signals mediated by Src family kinases are essential for the survival of naive T cells
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Autor/in / Beteiligte Person: | Zamoyska, Rose ; Seddon, Benedict |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 169 (2002-09-10), Heft 6 |
Veröffentlichung: | 2002 |
Medientyp: | unknown |
ISSN: | 0022-1767 (print) |
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