The evaluation of patients with essential thrombocythemia in terms of risk of thrombosis
In: Revista da Associação Médica Brasileira v.67 n.3 2021 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Volume: 67, Issue: 3, Pages: 385-389, Published: 27 AUG, Jg. 67 (2021), Heft 3, S. 385-389
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SUMMARY OBJECTIVE: The aim of this study was to compare the incidence of factors associated with an increased risk of thrombosis in patients with essential thrombocythemia. METHODS: A total of 200 patients followed-up in our unit with a diagnosis of essential thrombocythemia in 13 years were analyzed retrospectively. RESULTS: Of the study participants, 60.5% were females and 39.5% were males, with an overall mean (±SD) age of 54.93 (±14.21) years. In 119 patients, Janus Kinase 2 was positive with 56.3% of cases. When two patient categories were defined as those with or without history of thrombosis, no significant differences were found in terms of Janus Kinase 2 positivity, mean age, as well as white blood cells and platelet counts (p>0.05). Also, no significant differences in thrombotic event incidence were found between patient categories defined on the basis of cut-off values for white blood cells (cut-off values of 15×103/mm3 and 8.7×103/mm3) and platelets (cut-off values of 1500×103/mm3) (p>0.05). CONCLUSION: Although our results are generally in line with the published data, some divergence from previous results has been observed with respect to risk factors for thrombotic events. Absence of a correlation between leukocytosis and thrombosis may be related with the significant decline in white blood cells after treatment. Also, a significant reduction in platelet counts occurring in association with treatment is linked with a lowered incidence of thrombosis. Janus Kinase 2-positive patients had a similar thrombosis frequency with that reported in the literature.
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The evaluation of patients with essential thrombocythemia in terms of risk of thrombosis
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Autor/in / Beteiligte Person: | Sunu, Cenk ; Ahmet Kursad Gunes ; Gulten Korkmaz Akat ; Kalpakci, Yasin ; Ceran, Funda ; Dagdas, Simten ; Ozet, Gulsum |
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Zeitschrift: | Revista da Associação Médica Brasileira v.67 n.3 2021 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Volume: 67, Issue: 3, Pages: 385-389, Published: 27 AUG, Jg. 67 (2021), Heft 3, S. 385-389 |
Veröffentlichung: | FapUNIFESP (SciELO), 2021 |
Medientyp: | unknown |
ISSN: | 1806-9282 (print) ; 0104-4230 (print) |
DOI: | 10.1590/1806-9282.20200778 |
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