Cardiovascular effects of verapamil in patients with essential hypertension
In: Circulation, Jg. 75 (1987-05-01), Heft 5
Online
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Zugriff:
The cardiovascular effects of intravenous verapamil and 3 months of oral administration of a slow-release form of verapamil (verapamil-SR) were studied in 10 patients with mild-to-moderate essential hypertension. Intravenous verapamil reduced arterial pressure by 15% (p less than .01) through a fall in total peripheral resistance of 29% (p less than .01); provoked a reflexive rise in heart rate (by 19%, p less than .02), cardiac output (by 74%, p less than .01), and plasma catecholamines; and shifted intravascular volume toward the cardiopulmonary circulation indicating peripheral venoconstriction. Quite in contrast to the immediate effects of the intravenous drug, oral therapy with verapamil-SR for 2 to 3 months lowered arterial pressure effectively (by 15%, p less than .01) by inducing vasodilation of 15% (p less than .02), but without causing reflex tachycardia, activation of the sympathetic-adrenergic or renin-angiotensin systems, or volume expansion. Oral therapy with verapamil-SR preserved systemic and renal blood flow and slightly reduced cardiac mass (by 6%, p less than .05) and renal vascular resistance (by 25%, p less than .05). Whereas intravenous verapamil tended to depress myocardial contractility, oral verapamil-SR did not at all affect myocardial contractility or left ventricular function. These cardiovascular effects make verapamil-SR an excellent agent for long-term antihypertensive therapy.
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Cardiovascular effects of verapamil in patients with essential hypertension
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Autor/in / Beteiligte Person: | Garavaglia, Guillermo E. ; Nunez, Boris D. ; Schmieder, Roland E. ; Messerli, Franz H. |
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Zeitschrift: | Circulation, Jg. 75 (1987-05-01), Heft 5 |
Veröffentlichung: | 1987 |
Medientyp: | unknown |
ISSN: | 0009-7322 (print) |
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